Relative resistance of HEK293 cells overproducing MRP4
| IC50 | Relative Resistance | ||||
|---|---|---|---|---|---|
| HEK293 | HEK293/5I | HEK293/5E | HEK293/4.3 | HEK293/4.63 | |
| μM | |||||
| 6MP | 5.2 ± 0.9 | 3.11-a | 2.51-a | 2.7 ± 0.4 | 5.6 ± 2.4 |
| TG | 1 ± 0.2 | 2.11-a | 2.31-a | 2.6 ± 0.6 | 4.1 ± 0.1 |
Values are the concentration at which the growth inhibition was 50% of the maximum growth (IC50). The relative resistance is calculated as the IC50 ratio of the transduced cells and the parental cells. Data are the mean (± S.E.M.) of at least three experiments.
↵1-a Wijnholds et al. (2000).