Potencies of various mGlu1 receptor agonists and antagonists in inhibition of [3H]quisqualate binding to rat mGlu1a receptor CHO-dhfr- membranes.
| Compound | Ki | Hill Coefficient |
|---|---|---|
| μM | ||
| Quisqualate | 0.030 ± 0.00 | 0.98 ± 0.01 |
| Glutamate | 0.40 ± 0.07 | 0.99 ± 0.01 |
| LY367385 | 1.18 ± 0.47 | 0.99 ± 0.01 |
| (S)-3,5-DHPG | 1.42 ± 0.00 | 0.97 ± 0.00 |
| (S)-4C3HPG | 1.65 ± 0.06 | 0.98 ± 0.02 |
| (1S,3R)-ACPD | 1.92 ± 0.20 | 0.97 ± 0.01 |
| (S)-4CPG | 4.51 ± 0.78 | 0.98 ± 0.00 |
| AIDA | 98.3 ± 15.4 | 0.98 ± 0.03 |
| MCPG | 165 ± 0.47 | 0.96 ± 0.02 |
| R214127 | >1,000 | |
| NPS 2390 | >1,000 | |
| BAY 36–7620 | >1,000 | |
| CPCCOEt | >1,000 |
Ki values and Hill coefficients are mean ± S.D. of two independent experiments.