TABLE 2

Effects of isoflurane and propofol on of Na+ current recovery from inactivation

−90 mV −70 mV
Holding Potential λ Ratio λ Ratio
ms ms
Control 3.4±0.2 9.3±0.2††
Isoflurane 0.4 mM 6.6±0.3 2.1±0.5 14.3±0.4 1.7±0.8
Isoflurane 0.8 mM 8.8±0.2** 2.4±0.8 17.1±1.4* 1.9±0.4
Control 3.9±0.2 8.5±0.3†
Propofol 2 μM 6.4±0.1 1.8±0.4 20.5±1.7* 2.8±0.7‡
Propofol 5 μM 10.5±0.9** 2.9±0.9 53.6±15.9** 5.7±1.6‡‡
  • * p < 0.05;

  • ** p < 0.01 versus respective control by ANOVA with Dunnett's post hoc test.

  • p < 0.05;

  • †† p < 0.01 for control λ at −70 versus −90 mV by unpaired t test (n=5-8).

  • p < 0.05;

  • ‡‡ p < 0.01 for λ ratio (drug effect versus control) at −70 versus −90 mV by unpaired t test (n=5-8).