Sensitivity of human cancer cell lines to a 1-h exposure to DDP, CBDCA, and CuSO4 IC50 values are presented as mean ± S.D.
| DDP | CBDCA | CuSO4 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cell Type | IC50 | -Fold Resistant | p Value | IC50 | -Fold Resistant | p Value | IC50 | -Fold Resistant | p Value |
| μM | μM | μM | |||||||
| IGROV-1/EV | 3.5 ± 0.6 | 65.8 ± 9.4 | 1011 ± 142 | ||||||
| IGROV-1/ATP7B | 5.6 ± 0.2 | 1.6 | <0.05 | 102.1 ± 2.2 | 1.6 | <0.05 | 1460 ± 159 | 1.4 | <0.05 |
| 2008/EV | 3.3 ± 0.5 | 43.9 ± 6.3 | 850 ± 52 | ||||||
| 2008/ATP7B | 8.7 ± 1.2 | 2.6 | <0.01 | 70.1 ± 4.1 | 1.6 | <0.01 | 1049 ± 75 | 1.2 | <0.05 |
| UMSCC10b/EV | 3.1 ± 0.3 | 81.7 ± 3.5 | 922 ± 69 | ||||||
| UMSCC10b/ATP7B | 5.2 ± 0.5 | 1.7 | <0.01 | 124.9 ± 12.8 | 1.5 | <0.05 | 1117 ± 92 | 1.2 | <0.05 |
EV, pRc/CMV empty vector transfected; ATP7B, pRc/CMV-ATP7B cDNA transfected.