TABLE 1

Activity of LY487379 on glutamate-induced [³⁵S]GTPγS binding.

Concentration-response curves were determined in the presence of 1 μM glutamate in membranes prepared from rat brain or recombinant cells expressing hmGlu2 receptors, or 10 nM glutamate for the hmGlu3 receptor preparation. Results are expressed as mean EC₅₀ values (lower-upper S.D.) and mean efficacy (E_max) ± S.E.M., expressed relative to the maximal stimulation achieved by glutamate alone. Summary data are calculated from three individual experiments performed in triplicate.