Cell Type and LPA Receptor Expression | Ligand | Ca2+ Response | Ca2+ Response to Ligand + 10 μM Ki16425 |
---|---|---|---|
THP-1 | LPA (nM) | ||
LPA1 | 10 | 432 ± 4 | 24 ± 5* |
LPA2 | ATP (nM) | ||
LPA4 | 300 | 231 ± 26 | 221 ± 27 |
PAF (nM) | |||
10 | 317 ± 32 | 295 ± 3 | |
SPC (μM) | |||
30 | 74 ± 8 | 65 ± 3 | |
3T3 | LPA (nM) | ||
LPA1 | 100 | 906 ± 60 | 151 ± 20* |
LPA2 | PDGF (pM) | ||
LPA4 | 40 | 419 ± 43 | 429 ± 7 |
400 | 793 ± 50 | 776 ± 2 | |
S1P (nM) | |||
10 | 451 ± 76 | 397 ± 49 | |
100 | 913 ± 80 | 820 ± 103 | |
A431 | LPA (nM) | ||
LPA1 | 10 | 711 ± 8 | 12 ± 5* |
LPA2 | EGF (nM) | ||
LPA3 | 16.7 | 206 ± 13 | 180 ± 5 |
PAF (nM) | |||
1 | 459 ± 32 | 385 ± 27 | |
PC-12 | LPA (nM) | ||
LPA1 | 10 | 64 ± 6 | 45 ± 5* |
100 | 362 ± 17 | 304 ± 13* | |
1000 | 375 ± 8 | 333 ± 22 | |
HL-60 | LPA (μM) | ||
LPA2 | 1 | 39 ± 3 | 37 ± 1 |
LPA4 | 10 | 41 ± 4 | 47 ± 8 |
SPC (μM) | |||
3 | 116 ± 23 | 111 ± 22 | |
30 | 305 ± 8 | 298 ± 51 | |
LPC (μM) | |||
3 | 34 ± 8 | 34 ± 10 | |
30 | 171 ± 33 | 157 ± 29 | |
Psy (μM) | |||
3 | 57 ± 5 | 63 ± 9 | |
30 | 176 ± 17 | 163 ± 2 | |
2AG (μM) | |||
26 | 39 ± 8 | 31 ± 6 |
LPC, lysophosphatidylcholine; Psy, psychosine; 2AG, 2-arachidonoylglycerol.
↵* The effect of Ki16425 is significant.