TABLE 3

Transcriptional responses of mouse F9 teratocarcinoma cells to activation of Frizzled-1 or Frizzled-2: DNA microarray (partial list) The products of the following genes were identified by gene profiling of mouse F9 teratocarcinoma cells expressing the rat Frizzled-1 (Rfz1) or the rat Frizzled-2 (Rfz2) chimera. Maximal change and time of response are shown.

Gene Accession No. ΔMax Time Description Reference
h
Rfz1 chimera
   Dishevelled 2 U24160 2.94 3.5 Phosphoprotein intermediated in Wnt signaling Capelluto et al.,2002
   Lefty1 D83921 1.83 3.5 TGF-beta-related gene of early embryonic patterning Kothapalli et al., 1997
   SRPK1 AB012290 1.46 16 Small nuclear ribonucleoprotein specific kinase 1 Gui et al., 1994
   Fcer Ig AV012229 2.94 16 Receptor for IgA Maliszewski et al., 1990
   Dnal4 BAA24153 1.81 16 ATPase dynein light chain 4 Ogawa et al., 1996
   Ephrin A3 U92885 1.91 16 Ligand for Eph receptor tyrosine kinase Cerretti et al., 1996
   BING-1 AF100956 3.06 16 Zinc finger protein Herberg et al., 1998
   JAB / SOCS1 Z47352 3.19 16 Janus kinase-binding protein Endo et al., 1997; Starr et al., 1997a,b
   Bip P20029 4 16 Member of hsp 70 family of chaperones Lee et al., 1999
   Rap-2b AI837726 4.19 16 Ras-related protein Ohmstede et al., 1990
   MyD118 P22339 9.93 16 Growth suppression and pro-apoptotic gene Abdollahi et al., 1991
   JIP1 AF003115 1.82 45 An inhibitor of c-Jun N-terminal kinase Yasuda et al., 1999
   Erk1 Z14249 1.83 45 Mitogen-activated protein kinase for cell proliferation Charest et al., 1993
   STAM U43900 2.41 45 Signal-transducing adaptor molecule of Janus kinase Takeshita et al., 1996
   Nip3 AF041054 4.98 45 E1B 19K/Bcl-2-binding protein Boyd et al., 1994
Rfz2 chimera
   sFRP-1 U88566 1.51 3.5 Soluble modulators of Wnt signaling Roth et al., 2000
   Lefty1 D83921 1.53 3.5 TGF-beta-related gene of early embryonic patterning Kothapalli et al., 1997
   Blast to hypothetical protein AA968123 2.67 3.5 Unknown
   MmZW10 AF003951 3.12 3.5 Cell division protein involved in chromosomal segregation Starr et al., 1997a,b
   Erk5 AB019373 2.79 6 Mitogen-activated protein kinase for cell proliferation Zhou et al., 1995
   Gnai 2 AI841629 1.9 16 G-alpha inhibitory protein of cell signaling Blatt et al., 1988
   JIP1 AF003115 2.29 16 An inhibitor of c-Jun N-terminal kinase Dickens et al., 1997
   Erk1 Z14249 2.52 16 Mitogen-activated protein kinase for cell proliferation Charest et al., 1993
   STAM U43900 3.05 16 Signal-transducing adaptor molecule of Janus kinase Takeshita et al., 1996
   MyD118 P22339 3.8 16 Growth suppression and pro-apoptotic gene Abdollahi et al., 1991
   Bip P20029 3.88 16 Member of hsp 70 family of chaperones Lee et al., 1999
   P-cadherin P10287 1.61 45 Ca2+-dependent adhesion protein in development Nose et al., 1986
   Nip3 AF041054 4.3 45 E1B 19K/Bcl-2-binding protein Boyd et al., 1994