TABLE 5

Effects of antisense (suppression) versus missense (control) ODNs to target those genes implicated in the formation of primitive endoderm in response to activation of the rat Frizzled-1 in mouse F9 teratocarcinoma clones expressing the Rfz1 chimera

Target ODN PE Formation
JAB Antisense Blocked
Mis-sense No Effect
Nip-3 Antisense Blocked
Mis-sense No Effect
Myd118 Antisense Blocked
Mis-sense No Effect
Ephrin A3 Antisense No Effect
Mis-sense No Effect
Msx-1 Antisense Enhanced
Mis-sense No Effect
Stam Antisense Enhanced
Mis-sense No Effect