Intramolecular atomic distances between pharmacophoric feature points All distances in Ångstroms. See Fig. 4, A-C, for details on relative positioning of pharmacophore features on representative ligands.
| hCNT1 | Hydr2 | AA1 | AA2 | AA3 |
|---|---|---|---|---|
| Hydr1 | 3.79a | 2.59 | 3.60 | 6.02 |
| Hydr2 | 3.94 | 1.20 | 2.56 | |
| AA1 | 4.00 | 5.97 | ||
| AA2 | 3.58 |
| hCNT2 | Hydr2 | AA1 | AA2 | AA3 | AA4 |
|---|---|---|---|---|---|
| Hydr1 | 3.49 | 2.95 | 3.52 | 5.54 | 2.75 |
| Hydr2 | 3.17 | 1.19 | 2.54 | 2.88 | |
| AA1 | 3.97 | 4.32 | 3.65 | ||
| AA2 | 3.50 | 2.99 | |||
| AA3 | 4.14 |
| hENT1 | Hydr2 | AA | AS | DS |
|---|---|---|---|---|
| Hydr1 | 3.79 | 3.60 | 7.00 | 7.21 |
| Hydr2 | 1.20 | 4.75 | 4.86 | |
| AA | 5.90 | 6.01 | ||
| DS | 0.26 |
AA, acceptor atom; Hydr, hydrophobic atom; AS, acceptor site; DS, donor site.