Comparison of BaP pharmacokinetic parameters in Cyp1a1(−/−) and Cyp1a1(+/+) mice
Individual mice (n = 3) were repeatedly tested at 10 time-points for Cyp1a1(−/−) and nine time-points for Cyp1a1(+/+) mice, following stomach gavage of BaP in corn oil at 15 mg/kg. For blood BaP levels in mice receiving BaP in the food, n was between 6 and 8 animals per group. Values are given as means ± S.D.
| Cyp1a1(−/−) | Cyp1a1(+/+) | |
|---|---|---|
| No TCDD pretreatment, BaP by gavage | ||
| AUC (min/g/ml) | 121 ± 8 | 32 ± 9 |
| Clearance (ml/min/kg) | 123 ± 10 | 490 ± 134 |
| Half-life (min) | 61 ± 13 | 31 ± 11 |
| TCDD pretreated, then BaP gavage | ||
| AUC (min/g/ml) | 119 ± 34 | 16 ± 5 |
| Clearance (ml/min/kg) | 135 ± 40 | 984 ± 310 |
| Half-life (min) | 63 ± 10 | 16 ± 3 |
| BaP concentration (ng/ml) in whole blood after BaP in the food | ||
| BaP, 125 mg/kg/day × 12 days | 103 ± 4.0 | 5.51 ± 2.1 |
| BaP, 12.5 mg/kg/day × 12 days | 3.68 ± 2.3 | <0.20 |
| BaP, 1.25 mg/kg/day × 12 days | 1.20 ± 0.7 | <0.20 |