IC50 values and calculated Ki values for antagonist inhibition of nicotine-stimulated dopamine release
| Inhibition of α-CtxMII-Resistant Response | Inhibition of α-CtxMII-Sensitive Response | |
|---|---|---|
| μM | μM | |
| DHβE | ||
| @ 10 μM NIC | 0.141 ± 0.013 | 1.86 ± 0.68 |
| @ 3 μM NIC | 0.059 ± 0.015 | 0.92 ± 0.34 |
| @ 1 μM NIC | 0.014 ± 0.003 | 0.079 ± 0.029 |
| Ki value | 0.020 ± 0.004 | 0.122 ± 0.040* |
| DEC | ||
| @ 10 μM NIC | 78.9 ± 11.0 | 257 ± 40 |
| @ 3 μM NIC | 16.8 ± 3.6 | 77.1 ± 40.4 |
| @ 1 μM NIC | 7.2 ± 2.3 | 17.5 ± 7.1 |
| Ki value | 9.6 ± 2.5 | 12.0 ± 3.5 |
| MLA | ||
| @ 10 μM NIC | 30.3 ± 5.7 | 8.32 ± 3.16 |
| @ 3 μM NIC | 9.24 ± 2.02 | 0.49 ± 0.16 |
| @ 1 μM NIC | 0.69 ± 0.41 | 0.32 ± 0.14 |
| Ki value | 1.02 ± 0.93 | 0.070 ± 0.018*** |
*, P < 0.05; ***, P < 0.001 by t test comparing Ki values for inhibition of α-CtxMII-resistant and -sensitive nicotine-stimulated dopamine release.