The effect of genotype on α-CtxMII resistant dopamine release from mouse striatal synaptosomes
The Rmax, EC50, and nH values of each genotype are presented. Data are presented as mean ± S.E.M.
| n | Rmax | EC50 | nH | |
|---|---|---|---|---|
| units | μM | |||
| α4 genotype | ||||
| +/+ | 4 | 11.31 ± 0.75 | 1.13 ± 0.24 | 0.87 ± 0.09 |
| +/− | 6 | 9.42 ± 0.82 | 0.86 ± 0.24 | 0.91 ± 0.15 |
| −/− | 4 | 0.21 ± 1.06 | ||
| α5 genotype | ||||
| +/+ | 6 | 9.54 ± 0.40 | 0.57 ± 0.08 | 1.05 ± 0.11 |
| +/− | 3 | 8.40 ± 0.11 | 0.41 ± 0.02 | 1.59 ± 0.09 |
| −/− | 6 | 3.54 ± 0.25 | 0.42 ± 0.10 | 1.30 ± 0.30 |
| α7 genotype | ||||
| +/+ | 7 | 9.22 ± 0.66 | 0.98 ± 0.22 | 0.95 ± 0.13 |
| +/− | 4 | 7.93 ± 0.50 | 0.71 ± 0.13 | 1.15 ± 0.18 |
| −/− | 7 | 8.28 ± 0.63 | 0.52 ± 0.13 | 1.11 ± 0.23 |
| β2 genotype | ||||
| +/+ | 5 | 9.80 ± 0.87 | 1.02 ± 0.28 | 0.96 ± 0.16 |
| +/− | 5 | 7.72 ± 0.81 | 1.43 ± 0.45 | 1.15 ± 0.18 |
| −/− | 3 | 0.20 ± 0.07 | ||
| β3 genotype | ||||
| +/+ | 4 | 9.89 ± 0.56 | 0.82 ± 0.15 | 0.99 ± 0.11 |
| +/− | 4 | 11.10 ± 0.68 | 0.72 ± 0.14 | 0.97 ± 0.13 |
| −/− | 5 | 12.09 ± 0.27 | 0.70 ± 0.54 | 0.87 ± 0.04 |
| β4 genotype | ||||
| +/+ | 3 | 9.57 ± 1.27 | 1.21 ± 0.54 | 0.80 ± 0.15 |
| +/− | 3 | 9.10 ± 0.81 | 1.29 ± 0.35 | 0.92 ± 0.13 |
| −/− | 3 | 10.00 ± 1.78 | 1.36 ± 0.87 | 0.71 ± 0.15 |