The effect of genotype on α-CtxMII sensitive dopamine release from mouse striatal synaptosomes
Rmax, EC50, and nH values of each genotype are presented. Data are presented as mean ± S.E.M.
| n | Rmax | EC50 | nH | |
|---|---|---|---|---|
| units | μM | |||
| α4 genotype | ||||
| +/+ | 4 | 2.96 ± 0.13 | 0.11 ± 0.02 | 1.34 ± 0.26 |
| +/− | 6 | 4.11 ± 0.38 | 0.18 ± 0.07 | 0.95 ± 0.27 |
| −/− | 4 | 1.33 ± 0.12 | 0.41 ± 0.25 | 1.04 ± 0.25 |
| α5 genotype | ||||
| +/+ | 6 | 3.41 ± 0.20 | 0.09 ± 0.02 | 1.41 ± 0.40 |
| +/− | 3 | 4.29 ± 0.25 | 0.09 ± 0.02 | 1.24 ± 0.31 |
| −/− | 6 | 5.53 ± 0.28 | 0.22 ± 0.04 | 1.16 ± 0.21 |
| α7 genotype | ||||
| +/+ | 6 | 3.48 ± 0.36 | 0.23 ± 0.09 | 0.90 ± 0.25 |
| +/− | 4 | 5.01 ± 0.95 | 0.45 ± 0.35 | 0.71 ± 0.24 |
| −/− | 8 | 3.09 ± 0.43 | 0.19 ± 0.12 | 0.72 ± 0.24 |
| β2 genotype | ||||
| +/+ | 5 | 3.40 ± 0.32 | 0.22 ± 0.08 | 1.11 ± 0.35 |
| +/− | 5 | 1.59 ± 0.15 | 0.11 ± 0.04 | 1.55 ± 0.76 |
| −/− | 3 | 0.15 ± 0.02 | ||
| β3 genotype | ||||
| +/+ | 4 | 3.10 ± 0.20 | 0.10 ± 0.02 | 1.21 ± 0.26 |
| +/− | 4 | 1.70 ± 0.36 | 0.05 ± 0.04 | 1.24 ± 1.05 |
| −/− | 5 | 0.75 ± 0.09 | 0.13 ± 0.05 | 1.65 ± 0.87 |
| β4 genotype | ||||
| +/+ | 3 | 3.73 ± 0.24 | 0.19 ± 0.04 | 1.90 ± 0.62 |
| +/− | 3 | 2.76 ± 0.37 | 0.17 ± 0.09 | 1.06 ± 0.48 |
| −/− | 3 | 2.94 ± 0.23 | 0.08 ± 0.03 | 1.13 ± 0.37 |