TABLE 1

Binding affinities and functional potencies of ligands for hD2L receptors in CHO cells

Binding data represent the mean ± S.E.M. from two independent experiments preformed in triplicate. Functional data represent the means ± S.E.M. from two to four independent experiments. See Materials and Methods for details.

Drug K0.5 Cyclase EC50 MAP kinase EC50 Cyclase K0.5/EC50 MAP kinase K0.5/EC50
nM
QP 221 ± 16 3.0 ± 0.5 4.1 ± 0.8 74.6 53.6
DHX 132 ± 18 113 ± 31 36 ± 9 1.2 3.7
DNS 59 ± 11 81 ± 17 74 ± 26 0.7 0.8
DNX 31 ± 10 5.7 ± 1.8 6.1 ± 1.0 5.5 5.2
RNPA 0.94 ± 0.01 0.011 ± 0.002 0.11 ± 0.01 80.8 8.8
SNPA 53 ± 11 10 ± 8.5 74 ± 14 5.1 0.7