TABLE 1

Expression levels of NMDA receptor mutants

Average NMDA currents before and after MTSEA modification are provided. The number of oocytes (N) is provided in Table 2.

Mutant Agonists Average Current Size
Full Partial Before After
nA
NR1 T518C Gly d-Ser 13,200 13,800
NR2 T518C Gly DCS 540 101
NR1 R523C d-Ser DCS 7800 2400
NR2 R523C d-Ser Gly 1312 240
NR1 V689C Gly d-Ser 7080 180
NR2 V689C Gly DCS 16,800 738
NR1 D732C Gly d-Ser 6600 6600
NR2 D732C Gly DCS 10,800 6000
NR2A T513C l-Glu NMDA 13,800 9600
NR2A R518C l-Glu d-Glu 1188 2020
NR2A T690C l-Asp l-Glu 4800 203
-
NR1 I691C Gly DCS 1079 603
- -
NR2A H485C l-Glu NMDA 1800 209
- -
NR2A S511C l-Glu l-Asp 6000 540