In vitro antiproliferative activity of JNJ-17029259
| Cell Line | IC50 |
|---|---|
| μM | |
| Human cancer cell lines | |
| HeLa | 2.12 ± 0.31 |
| HCT-116 | 2.74 ± 0.25 |
| SK-OV-3 | 1.43 ± 0.18 |
| PC3 | 1.84 ± 0.22 |
| A375 | 1.28 ± 0.04 |
| MDA-MB-231 | 2.77 ± 0.73 |
| Normal cell type | |
| MRC-5 | 3.43 ± 0.67 |
| HASMC | 3.68 ± 0.40 |
| MS1 | 3.74 ± 0.07 |
| HUVEC non-VEGF—stimulated | 2.57 ± 0.47 |
| HUVEC VEGF-stimulated | 0.1a |