JNJ-17029259 Dose | CAM Growth | Vein Lengthb | Artery Lengthc | Vein Diameterd |
---|---|---|---|---|
% | ||||
DMSO Only | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 |
5 nM | 103.5 ± 20.1 | 97.8 ± 13.8 | 101.7 ± 25.7 | 107.7 ± 25.1 |
10 nM | 97.4 ± 9.7 | 126.2 ± 15.9 | 97.3 ± 24.4 | 108.8 ± 13.1 |
20 nM | 80.1 ± 16.1 | 29.5 ± 13.7a | 30.2 ± 12.2a | 34.4 ± 10.6a |
30 nM | 67.9 ± 13.0 | 34.6 ± 25.4a | 16.1 ± 6.3a | 47.9 ± 16.0a |
40 nM | 79.2 ± 14.2 | 33.3 ± 18.8a | 28.8 ± 15.9a | 30.5 ± 14.8a |
50 nM | 56.7 ± 11.2 | 32.2 ± 22.4a | 11.7 ± 8.2a | 26.4 ± 18.5a |