TABLE 1

Blockade of DA and NE transporters uptake in rat cortical synaptosomes by bupropion and its hydroxy metabolites

Values given are mean ± S.D.

Drug IC50
[3H]DA [3H]NE
nM
Bupropion 550 ± 65 1900 ± 12
(2RS,3RS)-Hydroxybupropion >10,000 1700 ± 830
(2S,3S)-Hydroxybupropion 790 ± 11 520 ± 35
(2R,3R)-Hydroxybupropion >10,000 >10,000