Description of terms used and parameter values chosen for the mathematical model
| Term | Description | Value | Reference |
|---|---|---|---|
| [IL-2] | Serum concentration of IL-2 (molar units) | ||
| [IL-2 · α] | IL-2 in complex with IL-2Rα (molar units) | ||
| [α]0 | Total IL-2Rα on T cell surface | 100,000/cell | |
| t | Time (min) | ||
| A | Magnitude of fast component of double exponential clearance | 0.866 | Konrad et al. (1990) |
| k 1 | Rate constant for fast component of double exponential clearance | 0.0537 min-1 | Konrad et al. (1990) |
| B | Magnitude of slow component of double exponential clearance | 0.134 | Konrad et al. (1990) |
| k 2 | Rate constant for slow component of double exponential clearance | 0.00815 min-1 | Konrad et al. (1990) |
| k on | Association rate constant for IL-2-IL-2Rα interaction (wild-type) | 6 × 108 M-1 min-1 | Liparoto et al. (2002) |
| k off | Dissociation rate constant for IL-2-IL-2Rα interaction (wild-type) | 18 min-1 | Liparoto et al. (2002) |
| k ec | Rate constant for endocytosis and degradation of IL-2-IL-2Rα complex | 0.00024 min-1 | Hemar and Dautry-Varsat (1990) |
| n | Total number of activated T cells in circulation | 108 l-1 | Hodge et al. (2000); Storek et al. (2000) |
| N av | Avogadro number | 6.023 × 1023 |