TABLE 2
Summary concentration response data Summary of the concentration response data from wild-type HERG, F656A, Y652A, and V625A tail currents under the conditions listed. The fit of F656A block by propafenone resulted in an abnormally large Hill Slope (nH), probably caused by fitting of only three points of the curve; higher concentrations were associated with solubility issues as explained in the text. By fixing the Hill slope to 1, the IC50 was found to be 246 μM. The Hill slope of V625A may be slightly less than 1 because of the effects of this mutation on the selectivity of the channel. CI, confidence interval.