Mammalian genes | | | |
ErbB-2, ErbB-3
| Oncogenic Tyr-Kinase receptors | Cell cycle arrest | Beerli et al. (1998, 2000); Holbro et al. (2003); Lund et al. (2004) |
| | Control of breast cancer cell proliferation reporter assays | |
Utrophi promoter
| Duchenne muscular dystrophy | | Corbi et al. (2000) |
IGF2, H19
| Cancer, Beckwith-Wiedemann syndrome | Activation of endogenous promoter | Jouvenot et al. (2002) |
EPO
| Anemia | Endogenous regulation, DNAse protection assays | Zhang et al. (2000) |
VEGF-A
| Angiogenesis | Endogenous regulation, DNAse protection assays | Liu et al. (2001) |
| | Induction of Angiogenesis in mouse | Rebar et al. (2002) |
MDR1
| Multidrug resistance | Repression of endogenous gene, | Bartsevich et al. (2000) |
| | Sensitivity to doxorubicin | Xu et al. (2002) |
PPARĪ³ | Adipogenesis | Isoform-specific Inhibition of adipogenesis | Ren et al. (2002) |
BAX
| Apoptosis | Activation of endogenous gene, promotes p53 independent apoptosis | Falke et al. (2003) |
CHK2
| Cell cycle progression | Repression on endogenous gene | Tan et al. (2003) |
| | Suppresses p53 activation in response to DNA damage | |
CD144
| Angiogenesis, metastasis | Activation or repression using cell sorting | Blancafort et al. (2003) |
ICAM-1
| Cell adhesion | Activation or repression using cell sorting | Magnenat et al. (2004) |
OCT-4
| ES differentiation | Activation and repression of endogenous gene, regulation of lineage genes, morphological differentiation of ES cells | Bartsevich et al. (2003) |
Viral targets | | | |
HIV-1 (LTR) | | Transient Repression of HIV-1 transcription | Reynolds et al. (2003) |
| | Stable Inhibition of multiple HIV-1 isolates | Segal et al. (2004) |
HSV-1 (ICP4 promoter)
| | Inhibition of HSV-1 infection | Papworth et al. (2003) |
Plant genes | | | |
APETALA3 (AP3)
| Floral organ identity | Missing petals and petals to sepals transformations in transgenic plants | Guan et al. (2002) |