Estimated DPC and SSB in MJ-III-65 treated CEM cells
For comparison, DPC in CPT-treated cells was determined. Values obtained from independent experiments are listed. DNA lesion frequencies are expressed in Rad-equivalents (Ross et al., 1979; Kohn, 1991). In case of SSB, 1 Rad-equivalent corresponds to approximately 1 SSB/109 nucleotides.
| Drug | Concentration | DPC | SSB |
|---|---|---|---|
| μM | Rad-Eq | ||
| Untreated control | 0 | 0 | 0 |
| MJ-III-65 | 0.03 | 403, 433 | 378, 579 |
| MJ-III-65 | 0.1 | 845, 913 | 527, 894 |
| MJ-III-65 | 0.3 | 1274, 1288, 1410 | 531, 834 |
| CPT | 0.3 | 1720 | NT |
NT, not tested; Rad-Eq, Rad-equivalent.