Extent of tissue toxicity in the Null mice treated with acetaminophen at 600 mg/kg and in wild-type mice treated with acetaminophen at 400 mg/kg
Male 3-month-old wild-type and Null mice were treated with acetaminophen as described in Table 1 but at a differing dose that was found to produce equivalent serum acetaminophen levels. The severity of lesions in the tissues was graded: +, moderate; ±, mild; and -, negative.
| Tissue | Number of Mice in Each Grade | |||||
|---|---|---|---|---|---|---|
| Wild-Type (400 mg acetaminophen/kg) | Null (600 mg acetaminophen/kg) | |||||
| + | ± | - | + | ± | - | |
| Liver | 9 | 1 | 10 | |||
| Kidney | 2 | 5 | 3 | 10 | ||
| Lung | 9 | 1 | 2 | 8 | ||
| Nose | ||||||
| OE | 7 | 2 | 1 | 6 | 2 | 2 |
| Respiratory epithelium | 9 | 1 | 8 | 2 | ||
| LNG | 9 | 1 | 8 | 2 | ||