Binding affinities (Ki) of (E)- and (Z)-guggulsterone to the steroid receptors
| (E)-GS | (Z)-GS | |
|---|---|---|
| nM | ||
| GR | 252 ± 6 | 224 ± 26 |
| MR | 37 ± 2 | 39 ± 4 |
| AR | 315 ± 13 | 240 ± 21 |
| PR | 224 ± 6 | 201 ± 18 |
| ERα | >5000 | >5000 |
| ERβ | >5000 | >5000 |
| FXR | >5000 | >5000 |
| LXRα | >5000 | >5000 |
| TRα | >5000 | >5000 |
| TRβ | >5000 | >5000 |
| PPARα | >5000 | >5000 |
| PPARδ | >5000 | >5000 |
| PPARγ | >5000 | >5000 |
| RXRα | >5000 | >5000 |