TABLE 1

Accumulation of CDF in sandwich-cultured rat hepatocytes Values are presented as mean ± S.D.

Day CDF Accumulation BEI Clbile
In Cells + Bile In Cells
pmol / mg of protein % ml / min / kg
1 846.1 ± 98.4 815.8 ± 116.4 1 5.2 ± 5.2
2 614.5 ± 152.9 643.4 ± 124.9 0 0
3 479.9 ± 16.9 458.1 ± 4.1 4.7 1.7 ± 1.7
4 491.9 ± 28.1 351.3 ± 1.0 28.1 11.3 ± 2.2
  • BEI, biliary excretion index.