Relationship between potency of 873140 in the presence of test antagonists
| Test Antagonist | t Valuea | Significance | Slopeb | 95% Confidence Limits of Slope |
|---|---|---|---|---|
| TAK 779 | 8.17 | P < 0.0005 | −0.84 | −1.1 to −0.55 |
| Sch-C | 14.2 | P < 0.0005 | −1.18 | −1.1 to −0.9 |
| Sch-D | 15.1 | P < 0.0005 | −1.1 | −1.3 to −0.84 |
| UK-427,857 | 14.8 | P < 0.0005 | −1.0 | −1.3 to −0.8 |
↵ a Measure of the significance of a possible relationship between x and y values. In this case, x is the log of the ratio of IC50 values for the reference antagonist in the presence and absence of test antagonist (abscissae as for Fig. 11) and y is the log of the ratio of B0 values in the presence and absence of test antagonist (ordinates as for Fig. 11). See Materials and Methods for further details.