TABLE 1

GPCR sorting motifs, modifications, and molecules

Internalization Recycling Lysosomal Sorting
Modifications Phosphorylation Dephosphorylation Ubiquitination
Motifs Tyrosine-based Type I PDZ ligand Tyrosine-based
(-Y-X-X-ϕ-) Internal PDZ ligand (-Y-X-X-ϕ-)
Molecules Arrestins NHERF/EBP50 SNX1
NSF GASP
HRS/Vps4
  • GASP, G protein-coupled receptor associated protein; HRS, hepatocyte growth factor-regulated tyrosine kinase substrate; NSF, N-ethylmaleimide-sensitive factor; SNX1, sorting nexin1; Vps4, vacuolar protein sorting 4.