TABLE 1

AUC and F of male and female wild-type and Bcrp1–/– mice after oral and intravenous administration of nitrofurantoin

Mice received nitrofurantoin orally (10 mg/kg) or intravenously (5 mg/kg). Plasma levels were measured by HPLC to calculate the AUC, and F was calculated as described under Materials and Methods. Each value represents the mean ± S.D. (n = 3–6).

AUC oral AUC i.v. F
min · μg/ml %
Wild type
    Male 54.7 ± 6.8 96.0 ± 9.0 28.5 ± 7.6
    Female 113.0 ± 18.5* 159.9 ± 21.5* 35.3 ± 12.5
Bcrp1-/-
    Male 181.3 ± 30.8†† 167.4 ± 22.0†† 54.2 ± 19.7
    Female 182.5 ± 30.9†† 166.4 ± 15.9 54.8 ± 19.3
  • * P < 0.01, comparing difference between male and female mice.

  • P < 0.05, comparing difference between wild-type and Bcrp1-/- mice of the same sex.

  • †† P < 0.01, comparing difference between wild-type and Bcrp1-/- mice of the same sex.