TABLE 1

Chemical and hematological parameters of wild-type and Mrp3–/– mice

Blood and serum were analyzed for the indicated parameters. Groups consisted of three to five 10-week-old mice.

Parameter Male Mice Female Mice
Mrp3+/+Mrp3-/-Mrp3+/+Mrp3-/-
Hemoglobin (g/dl) 15.5 ± 0.4 17.0 ± 0.6 17.2 ± 1.0 14.6 ± 3.7
Hematocrit (%) 49.6 ± 5.2 55.2 ± 3.7 51.6 ± 3.3 46.0 ± 8.0
White blood cells (× 103/mm3) 3.3 ± 0.6 5.1 ± 1.5 4.8 ± 1.2 5.0 ± 1.0
Red blood cells (× 106/mm3) 9.1 ± 0.1 10.1 ± 0.8 10.5 ± 0.6 8.9 ± 1.2
Glucose (mg/dl) 158 ± 32 181 ± 41 174 ± 13 160 ± 26
Urea nitrogen (mg/dl) 26 ± 2 27 ± 2 25 ± 6 27 ± 3
Creatinine (mg/dl) 0.2 ± 0.1 0.3 ± 0.2 0.5 ± 0.1 0.3 ± 0.1
Total protein (g/dl) 5.8 ± 0.1 5.8 ± 0.3 5.4 ± 0.2 5.9 ± 0.3
Albumin (g/dl) 2.6 ± 0.1 3.2 ± 0.3 3.2 ± 0.1 3.4 ± 0.2
Bilirubin, total (mg/dl) 0.2 ± 0.1 0.2 ± 0.1 0.3 ± 0.1 0.3 ± 0.1
Alkaline phosphatase (U/l) 75 ± 63 132 ± 20 138 ± 10 152 ± 24
Alanine aminotransferase (U/l) 37 ± 14 62 ± 49 52 ± 16 33 ± 25
Aspartate aminotransferase (U/l) 151 ± 39 229 ± 116 100 ± 45 184 ± 141
Cholesterol (mg/dl) 99 ± 12 123 ± 7 80 ± 7 118 ± 7
Calcium (mg/dl) 9.4 ± 1.0 9.7 ± 0.6 9.4 ± 0.3 9.7 ± 0.4
Phosphorus (mg/dl) 7.7 ± 2.1 8.9 ± 2.6 7.3 ± 0.9 7.8 ± 1.4
Sodium (mEq/l) 160 ± 5 156 ± 5 148 ± 1 157 ± 7
Potassium (mEq/l) 7.7 ± 0.7 7.8 ± 1.2 6.8 ± 0.2 7.8 ± 1.3
Chloride (mEq/l) 98 ± 16 99 ± 13 87 ± 5 93 ± 10
Globulin (g/dl) 3.2 ± 0.4 2.6 ± 0.2 2.3 ± 0.2 2.5 ± 0.1