Toxicity of etoposide phosphate in wild-type and Mrp3-deficient mice
Groups of male mice (aged 8–12 weeks) were treated with varying amounts of etoposide phosphate administered as a single intraperitoneal injection. Dose values shown are milligrams of etoposide phosphate per kilogram of body weight. The values represent the number of surviving animals per group 4 weeks after treatment.
| Dose | Survival | |
|---|---|---|
| Mrp3+/+ | Mrp3-/- | |
| 125 mg/kg | 6/6 | 6/6 |
| 150 mg/kg | 13/13 | 11/13 |
| 175 mg/kg | 10/14 | 11/14 |
| 200 mg/kg | 7/18 | 7/18 |
| 225 mg/kg | 6/17 | 4/17 |
| 250 mg/kg | 0/5 | 0/5 |