Effects of thymidine and hypoxanthine on 5-fluorouracil, LY309887, and pemetrexed IC50 values
Shown are mean values ± S.E. of at least three independent experiments.
| A549 | Calu-1 | Calu-6 | |
|---|---|---|---|
| μg/ml | μg/ml | μg/ml | |
| 5-Fluorouracil | 1.04 ± 0.11 | 0.57 ± 0.04 | 0.47 ± 0.03 |
| + Thymidine | >100 | >100 | >100 |
| + Hypoxanthine | 1.26 ± 0.17 | 0.56 ± 0.02 | 0.77 ± 0.04 |
| LY309887 | 0.02 ± 0.01 | 1.64 ± 0.13 | 0.16 ± 0.05 |
| + Thymidine | 0.02 ± 0.01 | 1.86 ± 0.25 | 0.16 ± 0.03 |
| + Hypoxanthine | >100 | >100 | >100 |
| Pemetrexed | 0.25 ± 0.03 | 34.13 ± 5.78 | 4.83 ± 0.60 |
| + Thymidine | 0.85 ± 0.14 | 55.32 ± 4.41 | 5.96 ± 0.75 |
| + Hypoxanthine | 0.28 ± 0.04 | 36.23 ± 3.94 | 4.57 ± 0.56 |
| + Thymidine/hypoxanthine | >100 | >100 | >100 |