Pharmacokinetic parameters of pitavastatin during constant intravenous infusion into Sprague-Dawley (SD) rats and EHBRs
Data represent the mean ± S.E. (n = 4).
| Css,plasma | CLtotal | CLbile,plasma | CLbile,liver | Liver Concentration | Kp,liver | |
|---|---|---|---|---|---|---|
| ng · Eq/ml | ml/min/kg | ml/min/kg | ml/min/kg | ng · Eq/g | ||
| SD rat | 195 ± 13 | 6.26 ± 0.49 | 4.55 ± 0.13 | 0.248 ± 0.042 | 4346 ± 406 | 23.0 ± 3.6 |
| EHBR | 179 ± 8 | 6.75 ± 0.34 | 5.77 ± 0.53 | 0.399 ± 0.049 | 2621 ± 139** | 14.7 ± 0.8 |
Css,plasma, plasma steady-state concentration (mean of plasma concentration at 210 min); CL total, total plasma clearance obtained by dividing the infusion rate by C ss,plasma; CLbile,plasma, biliary clearance normalized by the plasma concentration; CLbile,liver, biliary clearance normalized by the liver concentration; Kp,liver, Kp value obtained by dividing the liver concentration by C ss,plasma (at 210 min).
↵** P < 0.01.