Pharmacokinetic parameters of pitavastatin during constant intravenous infusion into wild-type and Bcrp1(−/−) mice Data represent the mean ± S.E. (n = 4).
| Css,plasma | CLtotal | CLbile,plasma | CLbile,liver | Liver Concentration | Kp,liver | |
|---|---|---|---|---|---|---|
| ng/ml | ml/min/kg | ml/min/kg | ml/min/kg | ng/g | ||
| Wild type | 254 ± 21 | 20.1 ± 1.8 | 1.21 ± 0.43 | 0.364 ± 0.032 | 813 ± 196 | 3.34 ± 1.03 |
| Bcrp1(−/−) | 213 ± 22 | 24.2 ± 2.5 | 0.110 ± 0.02* | 0.0293 ± 0.0036** | 798 ± 124 | 3.94 ± 0.83 |
*P <0.05; ** P < 0.01.
Css,plasma, plasma steady-state concentration (mean of plasma concentration at 150 min); CLtotal, total plasma clearance obtained by dividing the infusion rate by Css,plasma; CLbile,plasma, biliary clearance normalized by the plasma concentration; CLbile,liver, biliary clearance normalized by the liver concentration; Kp,liver, Kp value obtained by dividing the liver concentration by Css,plasma (at 150 min).