TABLE 3

Pharmacokinetic parameters of pitavastatin during constant intravenous infusion into wild-type and Bcrp1(−/−) mice Data represent the mean ± S.E. (n = 4).

Css,plasma CLtotal CLbile,plasma CLbile,liver Liver Concentration Kp,liver
ng/ml ml/min/kg ml/min/kg ml/min/kg ng/g
Wild type 254 ± 21 20.1 ± 1.8 1.21 ± 0.43 0.364 ± 0.032 813 ± 196 3.34 ± 1.03
Bcrp1(−/−) 213 ± 22 24.2 ± 2.5 0.110 ± 0.02* 0.0293 ± 0.0036** 798 ± 124 3.94 ± 0.83
  • *P <0.05; ** P < 0.01.

    Css,plasma, plasma steady-state concentration (mean of plasma concentration at 150 min); CLtotal, total plasma clearance obtained by dividing the infusion rate by Css,plasma; CLbile,plasma, biliary clearance normalized by the plasma concentration; CLbile,liver, biliary clearance normalized by the liver concentration; Kp,liver, Kp value obtained by dividing the liver concentration by Css,plasma (at 150 min).