Intrinsic properties of hKv1.3 wild type and mutants in transiently transfected COS-7 cells
All values are given as mean ± S.D.; numbers of independent experiments are given in parentheses.
| hKv1.3 | |||
|---|---|---|---|
| Wild Type | H399T | A413C/H399T | |
| V1/2 (mV) | -33 ± 1 (2) | -36 ± 1 (9) | -37 ± 1 (3) |
| k (mV) | 10 ± 1 (2) | 7 ± 1 (9) | 7 ± 1 (3) |
| τm (ms) | 2.9 ± 0.4 (6) | 3.9 ± 0.7 (10) | 4.9 ± 1.1 (10) |
| τh at 40 mV (ms) | 291 ± 53 (6) | 678 ± 134 (10) | 1220 ± 200 (10) |
| τt at -60 mV (ms) | 117 (1) | 434 ± 119 (8) | 30 ± 14 (9) |
| τrec at -120 mV (s) | 13.6 ± 0.2 (4) | ≤ 1.1 (4) | ≤ 1.1 (4) |