IC50 values for steady state PAA block of hKv1.3 (H399T) and hKv1.3 (H399T/A413C) currents
All values were obtained from at least four independent experiments and are given as mean ± S.D.
| PAA | hKv1.3 (H399T) | hKv1.3 (A413C/H399T) |
|---|---|---|
| μM | ||
| (±)-Verapamil | 2.4 ± 0.2 | 267 ± 22 |
| (-)-Verapamil | 1.2 ± 0.2 | 258 ± 24 |
| (+)-Verapamil | 4.3 ± 0.5 | 356 ± 47 |
| (-)-Devapamil | 0.7 ± 0.1 | 66 ± 8 |
| (±)-Emopamil | 2.0 ± 0.2 | 25 ± 2a |
| (±)-Gallopamil | 3.4 ± 0.4 | 314 ± 29 |
| (±)-Norverapamil | 1.5 ± 0.3 | 228 ± 25 |
| (±)-Acyanoverapamil | 1.9 ± 0.2 | 246 ± 34 |
↵a Hill coefficient = 2.