Inhibition of CYP2A6 and CYP3A4 by selected psoralens The positive controls were tranylcypromine (CYP2A6) and ketoconazole (CYP3A4).
| Compound | IC50 | |
|---|---|---|
| CYP2A6 () | CYP3A4 | |
| μM | ||
| PAP-1 | 46 ± 7 | 2.35 ± 0.07 |
| AS-78 | >200 | 5.45 ± 0.08 |
| AS-77 | 2.1 ± 0.1 | >200 |
| PH-9 | 15 ± 1.4 | 14.5 ± 0.1 |
| 5-MOP | >200 | 6.85 ± 0.07 |
| Positive control | 0.17 ± 0.04 | 0.037 ± 0.005 |