TABLE 1
Allosteric TCM binding parameters for various modulators at mouse brain CB_{1} receptors p*K*_{B} is the negative logarithm of the equilibrium dissociation constant for the allosteric modulator at the free receptor, determined using nonlinear regression according to eq. 2 under *Materials and Methods*. Values represent the mean ± S.E.M. of four to eight experiments. For these analyses, the negative logarithm of the *K*_{A} value (eq. 2) was fixed to nine for each radioligand, based on previous saturation binding assays. Log α is the logarithm of the cooperativity factor. α is the antilogarithm (geometric mean) of the cooperativity factor with range in parentheses, based on the estimated log α values.