TABLE 4
Allosteric operational model binding parameters for various modulators at mouse vas deferens CB_{1} receptors All data sets (shown in Fig. 6) were globally analyzed using eq. 5 under *Materials and Methods*. The best-fit parameter values describing the activity of WIN 55,212 across the data sets were as follows: p*K*_{A} = 6.86 ± 0.28; Log τ = 1.97 ± 0.33; *E*_{m} = 82.7 ± 3.6; and *n* = 0.86 ± 0.18. p*K*_{B} is the negative logarithm of the equilibrium dissociation constant for the allosteric modulator at the free receptor, determined using nonlinear regression according to eq. 2 under *Materials and Methods*. Values represent the mean ± S.E. of four to eight experiments. Log α is the logarithm of the cooperativity factor. α is the antilogarithm (geometric mean) of the cooperativity factor, based on the estimated log α values. β is the empirical coupling constant, quantifying the fractional stimulus imparted by the modulator-occupied ternary complex.