Modulator & Parameter | Modulator Concentration | ||||||
---|---|---|---|---|---|---|---|
0 (Vehicle) | 3 nM | 10 nM | 30 nM | 100 nM | 300 nM | 1 μM | |
Org 27569 | |||||||
Emax | 123 (118–127) | 135 (132–138) | 93 (91–96) | 46 (45–48) | 3.81 (3.45–4.17) | ||
pEC50 | 8.29 ± 0.07 | 8.67 ± 0.04** | 9.01 ± 0.05** | 9.30 ± 0.09** | |||
Org 27759 | |||||||
Emax | 103 (100–106) | 104 (102–106) | 93 (91–95) | 69 (68–71) | 26 (25–27) | ||
pEC50 | 8.22 ± 0.06 | 8.45 ± 0.03* | 8.56 ± 0.04** | 8.80 ± 0.04** | 9.50 ± 0.08** | ||
Org 29647 | |||||||
Emax | 105 (101–109) | 105 (100–109) | 108 (104–111) | 90 (87–92) | 52 (50–54) | 25 (23–26) | 4.75 (4.16–5.33) |
pEC50 | 8.59 ± 0.07 | 8.67 ± 0.08 | 8.56 ± 0.06 | 8.73 ± 0.06 | 9.17 ± 0.08** | 9.58 ± 0.12** |
↵** P < 0.01, one-way analysis of variance followed by Dunnett's post test