1,23R,25(OH)3D3 | 1,24S,25(OH)3D3 | 1,24R,25(OH)3D3 | Total Intrinsic Clearance | |||||
---|---|---|---|---|---|---|---|---|
Vmax | Km | Vmax | Km | Vmax | Km | Vmax/Km | ||
pmol/min/pmol | μM | pmol/min/pmol | μM | pmol/min/pmol | μM | ml/min/nmol | μl/min/mg | |
CYP3A4 (b5 co-expressed) | 6.5 ± 0.6 | 10.3 ± 2.5 | 1.1 ± 0.2 | 16.4 ± 7.8 | 0.70 | |||
Human liver microsomes | 152 ± 11a | 16.4 ± 2.8 | 79.6 ± 6.2a | 25.2 ± 3.9 | 0.21b | 12.4 | ||
Human jejunal homogenate | 11.6 ± 1.3a | 8.8 ± 2.6 | 7.2 ± 1.1a | 16.3 ± 5.2 | 0.16b | 1.8 | ||
CYP24A1 | 0.73 ± 0.22c | 0.06 ± 0.02c | 12.2 |