TABLE 3

Potencies (pEC0.5,diss) of diallylcaracurine V to retard [3H]NMS dissociation from the indicated wild-type and mutant receptors

ΔpEC0.5,diss indicates the difference between the pEC0.5,diss values for the mutant and for the respective wild-type receptor. Values are means ± S.E. of three to five separate experiments.

pEC0.5,diss ΔpEC0.5,diss (Mutant-Wild Type)
M2 wild type 7.93 ± 0.03
M2423T→A 7.27 ± 0.04 -0.66
M2423T→H 7.25 ± 0.06a -0.68
M5 wild type 5.57 ± 0.09
M5478H→A 6.15 ± 0.05 +0.58
M5478H→T 6.55 ± 0.05a +0.98
  • a Data are from Voigtländer et al. (2003).