Inhibition of PTPs by NSC-87877 in vitro
Each experiment was performed in triplicate or in duplicate. Data are presented as mean ± S.E.M.
| PTP | IC50 | IC50 Selectivity |
|---|---|---|
| μM | -fold | |
| Shp2 | 0.318 ± 0.049 (n = 11) | 1 |
| Shp1 | 0.355 ± 0.073 (n = 5) | 1 |
| PTP1B | 1.691 ± 0.407 (n = 4) | 5 |
| HePTP | 7.745 ± 1.561 (n = 4) | 24 |
| DEP1 | 65.617 ± 4.120 (n = 3) | 206 |
| CD45 | 84.473 ± 16.185 (n = 3) | 266 |
| LAR | 150.930 ± 9.077 (n = 4) | 475 |
| Shp2V280 | 1.110 ± 0.136 (n = 6) | 3 |
| Shp2RD | 1.087 ± 0.162 (n = 6) | 3 |