Ligand | Ki | Selectivity (Ki ratio: rat α3β4/rat α4β2) | ||||||
---|---|---|---|---|---|---|---|---|
α4β2 (rat) | α4β2 (human) | Forebrain (rat) | α3β4 (rat) | |||||
nM | ||||||||
Sazetidine-A | 0.41 ± 0.16 | 0.64 ± 0.32 | 0.94 ± 0.48 | 10,000 ± 3000 | 24,000 | |||
(−)-Nicotine | 10 ± 2 | 8.2 ± 0.2 | 12 ± 2 | 440 ± 60 | 44 | |||
DHβE | 600 ± 70 | 410 ± 30 | 130 ± 50 | 110,000 ± 10,000 | 180 |