Environmental regulator of HIF-1
Regulator | Function/Pathway Involved | Consequence | Reference |
|---|---|---|---|
| Nickel (Ni2+) | Decreases cellular Fe level | Increased HIF-1α | Davidson et al., 2005 |
| Inhibits PHDs | |||
| Down-regulates the expression of FIH-1 and ARD1 | Ke et al., 2005 | ||
| Depletes intracellular ascorbate | Salnikow et al., 2004 | ||
| PI3K/Akt | Li et al., 2004 | ||
| Cobalt (Co2+) | Replaces Fe | Increased HIF-1α | Yuan et al., 2003 |
| Down-regulates the expression of FIH-1 and ARD1 | Ke et al., 2005 | ||
| Depletes intracellular ascorbate | Salnikow et al., 2004 | ||
| PI3K | Increased HIF-1α | Gao et al., 2004 | |
| Arsenite | ROS | Duyndam et al., 2001 | |
| p38 MAPK | Duyndam et al., 2003 | ||
| Chromium | p38 MAPK, ROS | Increased HIF-1α | Gao et al., 2004 |
| PI3K/Akt, ROS | Increased HIF-1α | Gao et al., 2002 | |
| Vanadate | AMP-activated protein kinase (AMPK) | Hwang et al., 2004 | |
| Desferrioxamine (DFO) | Fe chelator | Increased HIF-1α | Wang and Semenza, 1993 |
| Insulin Interleukin-1 (IL-1) | PI3K | Increased HIF-1α | Stiehl et al., 2002 |
| Insulin-like growth factor (IGF)-1, IGF-2 | ROS | Increased HIF-1α | Feldser et al., 1999 |
| Fetal calf serum | ROS | Increased HIF-1α | Richard et al., 2000 |
| Angiotensin II (Ang II) | ROS | Increased HIF-1α | Gorlach et al., 2001 |
| Thrombin, Platelet-derived growth factor (PDGF) | |||
| Nitric oxide (NO) | MAPK, PI3K | Increased HIF-1α | Kasuno et al., 2004 |
| Inhibits PHDs | Metzen et al., 2003b | ||
| Nitric oxide (NO) under hypoxia | Inhibits mitochondrial O2 consumption | Decreased HIF-1α | Hagen et al., 2003 |
| Increases intracellular Fe and PHDs activity | Callapina et al., 2005 | ||
| TGF-α | ROS | Increased HIF-1α translocation and activity | Haddad and Land, 2001 |
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| Increased DNA binding |
Hellwig-Burgel et al., 1999
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