EC50 on cAMP and on MAPK of compounds tested on β1AR
Experimental data from Figs. 1A and 2B presented as mean ± S.E.M.
Ligand | EC50 | ||
|---|---|---|---|
| cAMP | MAPK | ||
| nM | |||
| Isoproterenol | 4.61 ± 2.08 | 2147.17 ± 1162 | |
| Labetalol | 5.10 ± 3.42 | N.D. | |
| Bucindolol | 2.77 ± 1.16 | 14.25 ± 9.06 | |
| Carvedilol | 273.19 ± 212.52 | 74.59 ± 39.90 | |
| Propranolol | 33.31 ± 12.80 | 32.68 ± 19.02 | |
| Metoprolol | 141.68 ± 87.71 | N.D. | |
| Bisoprolol | 42.26 ± 18.20 | N.D. | |
| Atenolol | 312.47 ± 170.00 | N.D. | |
N.D., not determined.