Emax on cAMP and on MAPK of compounds tested on β2AR
Experimental data from Fig. 3B and 4A, presented as maximal response ± S.E.M. Data are expressed as percentage of the isoproterenol-stimulated response unless otherwise specified.
Emax | |||
---|---|---|---|
Ligand | cAMP | MAPK | |
Isoproterenol | 100 | 100 | |
Labetalol | 31.5 ± 1.7 | 64.1 ± 7.3 | |
Bucindolol | −2.8 ± 1.8a | 64.8 ± 8.3 | |
Carvedilol | −6.7 ± 7.0a | 38.12 ± 6.4 | |
Propranolol | −43.9 ± 7.6a | 40.6 ± 4.5 | |
Metoprolol | −59.2 ± 9.0a | −41.2 ± 11.5b | |
Bisoprolol | −59.4 ± 12.0a | −51.6 ± 7.7b | |
Atenolol | −59.5 ± 10.8a | −55.8 ± 9.8b |