TABLE 3
Binding affinities of flunitrazepam and zolpidem for α1β2γ2s WT and α1β2γ2s mutant receptors
Values shown are the mean ± S.E.M. for n number of independent experiments. KI is the equilibrium dissociation constant (apparent affinity) of the unlabeled ligand. KI values were determined by the displacement of [3H]flunitrazepam. Statistical differences between WT and chimera logKI values were determined using one-way ANOVA with Dunnett's post test.