TABLE 2

Pharmacokinetic parameters of tenofovir during constant infusion into wild-type and Mrp4 knockout mice

Data are taken from Fig. 7, D-F. Data represent the mean ± S.E. (n = 3).

	CL_total	CL_renal,plasma	CL_renal,kidney	GFR	K_p,kidney	K_p,liver	K_p,brain
		ml/min/kg
Wild type	28.0 ± 2.2	24.9 ± 0.7	0.860 ± 0.073	14.5 ± 1.2	12.7 ± 0.3	1.17 ± 0.16	0.0146 ± 0.0029
Mrp4(−/−)	28.1 ± 2.0	26.0 ± 1.3	0.394 ± 0.079^*	14.8 ± 2.1	29.5 ± 5.5^*	1.31 ± 0.15	0.0191 ± 0.0110

K_{p, kidney}; K_p, value obtained by dividing the kidney concentration by C_ss,plasma (at 90 min).
↵* P < 0.05 statistically significant difference.