TABLE 3

K_iapp values for the inhibition of hiCE, hCE1, rCE, hAChE, or hBChE after preincubation of the enzymes with the TFK analogs for 24 h

Data were analyzed using Eq. 1 and are presented ± S.E.

ID	K_iapp
ID		hiCE	hCE1	rCE	hAChE	hBChE
			nM
1	64.9 ± 22.2^a	24.7 ± 5.0^a	46.7 ± 12.9^a	>100,000	2550 ± 310^b
2	4.50 ± 1.10^a	0.44 ± 0.08^b	1.10 ± 0.11^b	>100,000	>100,000
3	0.84 ± 0.17^b	0.36 ± 0.05^c	0.66 ± 0.06^b	>100,000	>100,000
4	59.2 ± 17.5^a	11.3 ± 3.0^a	29.0 ± 4.0^a	16,200 ± 3300^a	95,000 ± 6700^a
5	6.60 ± 0.87^a	0.49 ± 0.08^c	16.1 ± 1.4^a	>100,000	>100,000
6	0.75 ± 0.17^b	0.86 ± 0.20^a	1.35 ± 0.10^b	>100,000	>100,000
7	25,200 ± 2100^a	6.50 ± 0.64^d	20,500 ± 3800^a	>100,000	>100,000
8	3.60 ± 0.64^b	4.24 ± 0.81^b	42.6 ± 5.2^a	1630 ± 500^b	40,400 ± 5100^a
9	4.90 ± 0.89^a	1.22 ± 0.10^b	4.70 ± 0.54^b	>100,000	>100,000
10	33.0 ± 7.5^a	0.59 ± 0.10^c	22.8 ± 3.4^a	>100,000	>100,000
11	67.7 ± 10.1^a	14.1 ± 2.8^d	10.1 ± 1.1^c	>100,000	>100,000
12	0.79 ± 0.05^b	3.50 ± 0.30^b	89.8 ± 11.8^a	>100,000	>100,000
13	3.0 ± 0.3^b	2.36 ± 0.26^a	19.5 ± 3.1^b	>100,000	>100,000
14	1.20 ± 0.16^b	2.65 ± 0.45^a	11.3 ± 0.8^d ^a	>100,000	>100,000
15	>100,000	>100,000	>100,000	>100,000	>100,000
16	450 ± 100^b	3610 ± 1600^a	18,300 ± 3900^a	>100,000	>100,000
17	>100,000	>100,000	>100,000	>100,000	>100,000
18	17.0 ± 2.0^b	13.5 ± 2.2^a	45.8 ± 8.8^a	31,400 ± 7500^a	>100,000
19	0.20 ± 0.09^b	32.9 ± 8.0^a	268 ± 30^a	>100,000	>100,000
20	62.1 ± 10.4^a	16.9 ± 4.2^d	42.4 ± 7.7^a	360 ± 35^b	>100,000
21	376 ± 77^a	4.70 ± 0.37^a	29.9 ± 10.7^a	>100,000	>100,000

Modes of enzyme inhibition are:
↵ a Partially noncompetitive.
↵ b Partially competitive.
↵ c Competitive.
↵ d Noncompetitive.