TABLE 1

Pharmacokinetic parameters of ceftizoxime and cefazolin during constant infusion into wild-type and Mrp4-/- mice

Data are taken from Figure 5 and represent the mean ± S.E. GFR was determined by the renal clearance of inulin, which was 8.59 ± 0.80 and 11.9 ± 1.2 ml/min/kg in wild-type and Mrp4-/- mice, respectively. The unbound fractions of ceftizoxime and cefazolin have been reported to be 0.7 and 0.2, respectively (Tawara et al., 1992).




CLtotal

CLrenal,p

fp × GFR

CLrenal,k

Kp,kidney
ml / min / kg
Ceftizoxime
    Wild-type (n = 7) 13.2 ± 1.1 13.0 ± 1.3 6.01 ± 0.56 14.2 ± 3.2 0.528 ± 0.041
    Mrp4-/- (n = 10) 13.2 ± 1.4 9.76 ± 1.28 8.33 ± 0.84 1.06 ± 1.03** 1.04 ± 0.09**
Cefazolin
    Wild-type (n = 6) 13.8 ± 1.2 12.6 ± 1.2 1.72 ± 0.16 8.82 ± 1.99 1.39 ± 0.21
    Mrp4-/- (n = 5)
11.2 ± 1.4
10.4 ± 1.6
2.38 ± 0.24
2.97 ± 0.74*
3.75 ± 0.79*
  • CLtotal, total body clearance; CLrenal,p, renal clearance with respect to circulating plasma; CLrenal,k, renal clearance with respect to the kidney concentration; Kp,kidney, Kp value obtained by dividing the kidney concentration by Css,p (at 90 min).

  • * P < 0.05, significantly different from wild-type mice.

  • ** P < 0.01, significantly different from wild-type mice.